Brief Guidelines for Methods and Statistics in Medical Research

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This Guide to Statistics and Methods details the Metabolic and Bariatric Surgery Accreditation and Quality Improvement Program public user file data set for quality and outcomes reporting. This Guide to Statistics and Methods summarizes the advent, data considerations, utility and unique features, and statistical considerations of the Veterans Affairs National Surgical Quality Improvement Program for use in surgical quality improvement research.

This JAMA Guide to Statistics and Methods explains the correct usage of odds ratios in the clinical literature to report the strength of the association between binary outcomes. All Rights Reserved. Guide to Statistics and Medicine Explore this JAMA essay series that explains statistical techniques in clinical research to help clinicians interpret and critically appraise the medical literature.

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Statistics Guide for Research Grant Applicants

Review Research, Methods, Statistics. Full Text pdf link PDF. Full Text pdf link PDF has multimedia with quiz. Featured article: Systematic or scoping review?

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Explaining differential item functioning focusing on the crucial role of external information — an example from the measurement of adolescent mental health Authors: Curt Hagquist. Most recent articles RSS View all articles.


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Aims and scope BMC Medical Research Methodology is an open access journal publishing original peer-reviewed research articles in methodological approaches to healthcare research. BMC Medical Research Methodology does not aim to publish articles describing scientific methods or techniques: these should be directed to the BMC journal covering the relevant biomedical subject area. BMC Series blog. Latest Tweets. Submit manuscript. Avoid relying solely on statistical hypothesis testing, such as P values, which fail to convey important information about effect size.

References for the design of the study and statistical methods should be to standard works when possible with pages stated.

Define statistical terms, abbreviations, and most symbols. In general, this principle requires reporting the descriptive statistics from which other statistics are derived, such as the numerators and denominators of percentages, especially in risk, odds, and hazards ratios. Likewise, P values are not sufficient for re-analysis. Preliminary analyses: Check for normality of distribution of your data and identify any statistical procedures used to modify raw data before analysis.


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  • Examples include mathematically transforming continuous measurements to make distributions closer to the normal distribution, creating ratios or other derived variables, and collapsing continuous data into categorical data or combining categories. For example: Unpaired or t-test for independent samples was used to compare continuous variable between groups with and without coronary heart disease. For simplicity, round as much as is reasonable.

    Statistical analyses and methods in the published literature: The SAMPL guidelines

    For example, mean age can often be rounded to the nearest year without compromising either the clinical or the statistical analysis. If the smallest meaningful difference on a scale is 5 points, scores can be reported as whole numbers; decimals are not necessary.

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    Report the upper and lower boundaries of interpercentile ranges and the minimum and maximum values of ranges. There might be nonlinear relationship, which can be seen from scatterplot — see below.

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